Category: SoCs
Tool: SoC EDS
Device: Arria® 10


Is possible.
The Arria 10 SoC Development Kit example design, GHRD, uses UART with Dedicated I/O, but runs without the RTS/CTS signals.
If you use bare metal, HWLIB has an API to disable Automatic Flow Control that you can use.

<Quartus® Prime installation>\embedded\ip\altera\hps\altera_hps\hwlib\src\hwmgr\alt_16550_uart.c
(excerpt)
L.1125 alt_16550_flowcontrol_disable(ALT_16550_HANDLE_t * handle);